Killed but Metabolically Active Bacillus anthracis Vaccines Induce Broad and Protective Immunity against Anthrax
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چکیده
منابع مشابه
Anthrax, but Not Bacillus anthracis?
B acillus anthracis, the etiologic agent of anthrax, is a close relative of B. cereus, a soil organism and known opportunistic pathogen that causes a variety of human infections [1]. B. anthracis is very similar to B. cereus and B. thuringiensis except that all confirmed samples of B. anthracis suggest that it is a monophyletic clone derived from the B. cereus and B. thuringiensis clade. The ma...
متن کاملIn Silico Prediction of B-Cell and T-Cell Epitopes of Protective Antigen of Bacillus anthracis in Development of Vaccines Against Anthrax
Protective antigen (PA), a subunit of anthrax toxin from Bacillus anthracis, is known as a dominant component in subunit vaccines in protection against anthrax. In order to avoid the side effects of live attenuated and killed organisms, the use of linear neutralizing epitopes of PA is recommended in order to design recombinant vaccines. The present study is aimed at determining the dominant epi...
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Several highly attenuated spore-forming nontoxinogenic and nonencapsulated Bacillus anthracis vaccines differing in levels of expression of recombinant protective antigen (rPA) were constructed. Biochemical analyses (including electrospray mass spectroscopy and N terminus amino acid sequencing) as well as biological and immunological tests demonstrated that the rPA retains the characteristics o...
متن کاملHuman monoclonal antibodies against anthrax lethal factor and protective antigen act independently to protect against Bacillus anthracis infection and enhance endogenous immunity to anthrax.
The unpredictable nature of bioterrorism and the absence of real-time detection systems have highlighted the need for an efficient postexposure therapy for Bacillus anthracis infection. One approach is passive immunization through the administration of antibodies that mitigate the biological action of anthrax toxin. We isolated and characterized two protective fully human monoclonal antibodies ...
متن کاملAnthrax: Biology of Bacillus anthracis
Perhaps no other microorganism has received as much attention for its use as a potential agent for bioterrorism as Bacillus anthracis. In spite of the fact that the organism has been known for a very long time, limited progress has been made in developing a vaccine or understanding its biochemical and genetic properties. The genus Bacillus includes aerobic bacilli forming heatresistant spores. ...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2009
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.00530-08